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Presympto

"Detection before disease"

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What is Pronucleon™ Technology?

Pronucleon™ is a platform technology using custom-synthesized peptides that allow signal amplification to map the surface of rare proteins. Unlike the Presympto platform, recognition molecules used in currently available diagnostic assays for amyloid proteins (e.g. antibodies, aptamers) are not particularly sensitive to protein conformational state.

Presympto has created peptides specific for detection of oligomer and fibrillar forms of Aβ.

 

What are the Market Opportunities?

Alzheimer’s Disease

  • Pronucleon™, for Aβ cascade element detection
    • Bodily fluid (CSF, blood, tissue) based assays
    • Ophthalmic imaging
    • Brain imaging

Other Misfolding Protein Diseases

  • Prion-related
  • Parkinson’s
  • Amyotrophic lateral sclerosis

Therapeutic Potential


Molecular dynamic modeling used to generate next generation probes for early disease causing aggregates of amyloid

Published Ab42 Fiber Structure * T. Petkova, W. M. Yau, and R. Tycko, "Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils", Biochemistry 45, 498-512 (2006